WAY-100135 (dihydrochloride)

WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic 5-HT1A receptor, with an IC50 of 34 nM at the rat hippocampal 5-HT1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties[1][2].

Product Specifications

CAS Number

[149055-79-8]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/way-100135-dihydrochloride.html

Purity

98.14

Solubility

H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC(C)(C)C)C(C1=CC=CC=C1)CN2CCN(C3=CC=CC=C3OC)CC2.[H]Cl.[H]Cl

Molecular Formula

C24H35Cl2N3O2

Molecular Weight

468.46

References & Citations

[1]Fletcher A, et, al. WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur J Pharmacol. 1993 Jun 24;237 (2-3) :283-91.|[2]Han L, et, al. 5-HT 1A receptor-mediated attenuation of synaptic transmission in rat medial vestibular nucleus impacts on vestibular-related motor function. J Physiol. 2021 Jan;599 (1) :253-267.