ZNL-0056
ZNL-0056 is an orally active ATP-competitive inhibitor that targets both the Cys797 and Cys775 in the ATP binding site of EGFR. ZNL-0056 selectively inhibits EGFR and its downstream signaling in H3255 cells. ZNL-0056 can be used for the research of cancer[1].
Product Specifications
CAS Number
2767987-38-0
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/znl-0056.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CSC(NC(C=C)=O)=C1)NC2=NC3=CC=CC(C)=C3N2[C@H]4CN(CCCC4)C(C=C)=O
Molecular Formula
C25H27N5O3S
Molecular Weight
477.58
References & Citations
[1]Li Z, et al. Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality. ACS Central Science. 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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