Human CNOT8 Protein

<strong>Human CNOT8 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2011994_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 250 µg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> CCR4-NOT transcription complex subunit 8 protein, CAF1 protein, CALIF protein, hCAF1 protein, POP2 protein, CNOT8, CNOT 8, CNOT-8, CNOT8 protein, CNOT 8 protein, CNOT-8 protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Du H, Zhao Y, He J, Zhang Y, Xi H, Liu M, Ma J, Wu L. YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex Nat Commun. 2016 Aug 25;7:12626._x000D_ 2: Doidge R, Mittal S, Aslam A, Winkler GS. Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex Biochem Soc Trans. 2012 Aug;40(4):896-901._x000D_ 3: Winkler GS. The mammalian anti-proliferative BTG/Tob protein family J Cell Physiol. 2010 Jan;222(1):66-72._x000D_ 4: Collart MA, Panasenko OO. The Ccr4-Not Complex: Architecture and Structural Insights Subcell Biochem. 2017;83:349-379._x000D_ 5: Almasmoum HA, Airhihen B, Seedhouse C, Winkler GS. Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma Leuk Lymphoma. 2021 Feb;62(2):281-290._x000D_ 6: Eskandarian S, Grand R, Irani S, Saeedi M, Mirfakhraie R. Importance of CNOT8 Deadenylase Subunit in DNA Damage Responses Following Ionizing Radiation (IR) Rep Biochem Mol Biol. 2020 Jul;9(2):163-170._x000D_ 7: Zukeran A, Takahashi A, Takaoka S, Mohamed HMA, Suzuki T, Ikematsu S, Yamamoto T. The CCR4-NOT deadenylase activity contributes to generation of induced pluripotent stem cells Biochem Biophys Res Commun. 2016 May 27;474(2):233-239._x000D_ 8: Parris TZ, Vizlin-Hodzic D, Salmela S, Funa K. Tumorigenic effects of TLX overexpression in HEK 293T cells Cancer Rep (Hoboken). 2019 Oct;2(5):e1204._x000D_ 9: Maryati M, Airhihen B, Winkler GS. The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module Biochem J. 2015 Jul 1;469(1):169-76._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/33006227">10: Russo D, Travaglino A, Varricchio S, Merolla F, Ilardi G, Raffone A, Scalvenzi M, Costa C, Fabbrocini G, Staibano S, Mascolo M. BRIT-1 expression and its relationship with PARP-1 and CAF-1/p60 in cutaneous melanoma J Eur Acad Dermatol Venereol. 2021 Apr;35(4):e254-e257. </a>_x000D_ _x000D_ <strong>Products Related to Human CNOT8 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>