SB-328437
SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM. SB-328437 can inhibit eosinophil migration induced by eotaxin, eotaxin-2, and monocyte chemotactic protein-4. In addition, SB-328437 can sensitize 5-FU -resistant gastric cancer cells. SB-328437 can also reduce the recruitment of neutrophils to the lungs and pulmonary inflammation during acute inflammation. SB-328437 can be used in the research of inflammation-related diseases[1][2][3].
Product Specifications
CAS Number
247580-43-4
UNSPSC
12352005
Hazard Statement
H302, H400
Target
CCR; Thymidylate Synthase
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sb-328437.html
Purity
99.58
Solubility
DMSO : 87.5 mg/mL (ultrasonic)
Smiles
O=C(OC)[C@H](CC1=CC=C([N+]([O-])=O)C=C1)NC(C2=C3C=CC=CC3=CC=C2)=O
Molecular Formula
C21H18N2O5
Molecular Weight
378.38
Precautions
H302, H400
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR3
Available Sizes
Frequently Asked Questions
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