GSK429286A
GSK429286A is a selective inhibitor of ROCK1 with an IC50 value of 14 nM.
Product Specifications
CAS Number
864082-47-3
UNSPSC
12352005
Hazard Statement
H301
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GSK429286A.html
Purity
99.13
Solubility
DMSO : ≥ 51 mg/mL
Smiles
O=C(C(C(C1=CC=C(C(F)(F)F)C=C1)C2)=C(C)NC2=O)NC3=CC4=C(NN=C4)C=C3F
Molecular Formula
C21H16F4N4O2
Molecular Weight
432.37
Precautions
H301
References & Citations
[1]Goodman KB et al Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11;50 (1) :6-9.|[2]Nichols RJ et al Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J. 2009 Oct 23;424 (1) :47-60.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK1
Available Sizes
Frequently Asked Questions
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