GSK429286A

GSK429286A is a selective inhibitor of ROCK1 with an IC50 value of 14 nM.

Product Specifications

CAS Number

[864082-47-3]

UNSPSC

12352005

Hazard Statement

H301

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GSK429286A.html

Purity

99.13

Solubility

DMSO : ≥ 51 mg/mL

Smiles

O=C(C(C(C1=CC=C(C(F)(F)F)C=C1)C2)=C(C)NC2=O)NC3=CC4=C(NN=C4)C=C3F

Molecular Formula

C21H16F4N4O2

Molecular Weight

432.37

Precautions

H301

References & Citations

[1]Goodman KB et al Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11;50 (1) :6-9.|[2]Nichols RJ et al Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J. 2009 Oct 23;424 (1) :47-60.