RUPB-61
RUPB-61 is a potent Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) inhibitor with an IC50 value of 13 nM. RUPB-61 shows antiparasitic activity[1].
Product Specifications
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pfpkg-in-2.html
Solubility
10 mM in DMSO
Smiles
FC(C=C1)=CC=C1C(NC([C@@H]2[C@H](C)CN(C)CC2)=C3)=C3C4=CC=NC=C4
Molecular Formula
C22H24FN3
Molecular Weight
349.44
References & Citations
[1]Gilleran JA, et al. Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. J Med Chem. 2024 Feb 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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