Formoterol-d3

Formoterol-d3 is deuterium labeled Arformoterol. Arformoterol ((R, R) -Formoterol), the (R, R) -enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol can be used for the research of chronic obstructive pulmonary disease (COPD) [1][2].

Product Specifications

CAS Number

[1198353-13-7]

UNSPSC

12352005

Hazard Statement

H332, H351, H361, H370, H372

Target

Adrenergic Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

99.60

Solubility

DMSO : 2 mg/mL (ultrasonic; warming)

Smiles

[2H]C([2H])([2H])OC(C=C1)=CC=C1C[C@@H](C)NC[C@@H](C2=CC(NC=O)=C(C=C2)O)O

Molecular Formula

C19H21D3N2O4

Molecular Weight

347.42

Precautions

H332, H351, H361, H370, H372

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Cazzola M, et, al. Arformoterol tartrate in the treatment of COPD. Expert Rev Respir Med. 2010 Apr;4 (2) :155-62.|[3]Handley DA, et, al. Biological actions of formoterol isomers. Pulm Pharmacol Ther. 2002;15 (2) :135-45.|[4]Song W, et, al. Postexposure administration of a {beta}2-agonist decreases chlorine-induced airway hyperreactivity in mice. Am J Respir Cell Mol Biol. 2011 Jul;45 (1) :88-94.