NSC 23766 (trihydrochloride)
NSC 23766 trihydrochloride is an inhibitor of Rac1 activation.
Product Specifications
CAS Number
[1177865-17-6]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Ras
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NSC-23766-trihydrochloride.html
Concentration
10mM
Purity
99.41
Solubility
DMSO : 33.33 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
NC1=CC(C)=NC2=CC=C(NC3=NC(NC(C)CCCN(CC)CC)=NC(C)=C3)C=C12.[H]Cl.[H]Cl.[H]Cl
Molecular Formula
C24H38Cl3N7
Molecular Weight
530.96
Precautions
H315, H319, H335
References & Citations
[1]Veluthakal R, et al. NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model. Cell Physiol Biochem. 2016;39 (2) :760-7.|[2]Song SJ, et al. Inhibition of Rac1 GTPase activity affects porcine oocyte maturation and early embryo development. Sci Rep. 2016 Oct 3;6:34415|[3]Zhao L, et al. Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep. 2016 Apr 6;6:23972|[4]Wang Y, et al. Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection. Br J Pharmacol. 2016 Mar;173 (5) :937-50
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Adv Sci (Weinh) . 2021 Mar 8;8 (10) :2004000.|Am J Physiol Cell Physiol. 2022 Mar 1;322 (3) :C496-C507.|Arch Toxicol. 2022 Jul;96 (7) :2113-2122.|Arch Toxicol. 2022 Nov;96 (11) :2913-2926.|CNS Neurosci Ther. 2021 May;27 (5) :564-576.|Comput Struct Biotechnol J. 2021;19:1933-1943.|Fish Shellfish Immunol. 2022 Oct:129:22-29.|Food Chem Toxicol. 2021 Feb:148:111926.|Food Funct. 2021 Jan 7;12 (1) :154-161.|Front Immunol. 2021 Aug 2:12:686846.|Front Immunol. 2021 Aug 2;12:686846.|Glia. 2023 Aug;71 (8) :1985-2004.|J Agric Food Chem. 2021 Nov 3;69 (43) :12862-12869.|J Inorg Biochem. 2022 Apr 20;233:111838.|J Inorg Biochem. 2022 Apr:229:111725.|J Virol. 2024 Dec 31:e0140824.|J Virol. 2025 Aug 25:e0022125.|Mol Immunol. 2022 Mar:143:135-146.|Nat Commun. 2025 Aug 5;16 (1) :7190.|Phytomedicine. 2024 Aug 27:134:155986.|Preprints. 2024 Aug 27.|Sci Adv. 2025 Oct 24;11 (43) :eads9181.|Virology. 2024 Dec:600:110233.|Bioact Mater. 2021 Jun 1:7:364-376.|Biochem Biophys Res Commun. 2025 Dec 31:793:153032.|Biochim Biophys Acta Mol Basis Dis. 2024 Mar 18;1870 (4) :167124.|Biol Pharm Bull. 2021 Sep 1;44 (9) :1263-1271.|bioRxiv. 2025 January 14.|BMC Cancer. 2025 May 28;25 (1) :956.|Cell Death Dis. 2022 Feb 17;13 (2) :158.|Cell Immunol. 2024 Jun 17:401-402:104843.|Cell Mol Life Sci. 2024 Dec 27;82 (1) :28.|Cell Rep Phys Sci. 2025 Oct 15;6 (10) .|Exp Mol Med. 2025 Feb;57 (1) :86-103.|Exp Ther Med. 2022 Jun 7;24 (2) :496.|Int Immunopharmacol. 2023 Apr:117:110014.|J Cell Commun Signal. 2023 Sep;17 (3) :723-736.|J Cell Mol Med. 2020 Mar;24 (6) :3582-3592.|Microsyst Nanoeng. 2024 Jul 15:10:97.|Mol Cell Endocrinol. 2022 Sep 15:555:111719.|Nat Immunol. 2025 Aug;26 (8) :1258-1266.|Nat Metab. 2022 Dec;4 (12) :1830-1846.|Poult Sci|Research Square Preprint. 2020 Jul.|Research Square Preprint. 2023 Sep 1.|Theoretical and Applied Mechanics Letters. 2025 Aug 22.|Vet Microbiol. 2022 Jun;269:109434.
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