SD 0006

SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α[1][2].

Product Specifications

CAS Number

[271576-80-8]

Product Name Alternative

SD-06

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; p38 MAPK

Type

Reference compound

Related Pathways

Autophagy; MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/SD-06.html

Concentration

10mM

Purity

98.22

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OCC(N1CCC(CC1)C2=NNC(C3=CC=C(C=C3)Cl)=C2C4=NC=NC=C4)=O

Molecular Formula

C20H20ClN5O2

Molecular Weight

397.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Burnette BL, et al. SD0006: a potent, selective and orally available inhibitor of p38 kinase. Pharmacology. 2009;84 (1) :42-60.|[2]Walker JK, et al. Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2010 Apr 15;20 (8) :2634-8.