What is the catalog number for SD 0006?

The catalog number for SD 0006 is HY-11087.

What sizes are available for SD 0006?

SD 0006 is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 50 mg, 100 mg.

How many pack sizes does SD 0006 come in?

SD 0006 is available in 5 different pack sizes.

SD 0006 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SD 0006?

SD 0006 is manufactured by QuantiMol.

What is the estimated delivery time for SD 0006?

Estimated delivery time for SD 0006 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for SD 0006?

The safety data sheet for SD 0006 is available here: http://file.medchemexpress.com/batch_PDF/HY-11087/SD-0006-SDS-MedChemExpress.pdf.

SD 0006

SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α[1][2].

Product Specifications

CAS Number

271576-80-8

Product Name Alternative

SD-06

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; p38 MAPK

Type

Reference compound

Related Pathways

Autophagy; MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/SD-06.html

Concentration

10mM

Purity

98.22

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OCC(N1CCC(CC1)C2=NNC(C3=CC=C(C=C3)Cl)=C2C4=NC=NC=C4)=O

Molecular Formula

C20H20ClN5O2

Molecular Weight

397.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Burnette BL, et al. SD0006: a potent, selective and orally available inhibitor of p38 kinase. Pharmacology. 2009;84 (1) :42-60.|[2]Walker JK, et al. Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2010 Apr 15;20 (8) :2634-8.