Mitoquinol

Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs[1][2][3].

Product Specifications

CAS Number

[845959-55-9]

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mitoquinol.html

Purity

98.00

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

CC1=C(CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(O)=C(OC)C(OC)=C1O.CS(=O)([O-])=O

Molecular Formula

C38H49O7PS

Molecular Weight

680.83

References & Citations

[1]Fink BD, et al. Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells. J Pharmacol Exp Ther. 2012 Sep;342 (3) :709-19. |[2]Mayorga EJ, et al. Therapeutic effects of mitoquinol during an acute heat stress challenge in growing barrows. J Anim Sci. 2024 Jan 3;102:skae161.|[3]Pant BD, et al. Mitoquinol improves phagocytosis and glycolysis in ethanol-exposed macrophages via HIF-1α-PFKP axis. J Immunol. 2025 May 12:vkaf078.