Fargesin

Fargesin is a bioactive neolignan isolated from magnolia plants, with antihypertensive and anti-inflammatory effects[1][2][3].

Product Specifications

CAS Number

[31008-19-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

AP-1

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/fargesin.html

Purity

99.52

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

COC1=CC=C([C@H]2OC[C@@]3([H])[C@H](C4=CC=C(OCO5)C5=C4)OC[C@]32[H])C=C1OC

Molecular Formula

C21H22O6

Molecular Weight

370.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Sha S, et al. Antihypertensive effects of fargesin in vitro and in vivo via attenuating oxidative stress and promoting nitric oxide release. Can J Physiol Pharmacol. 2016 Aug;94 (8) :900-6.|[2]Yue B, et al. Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice. Molecules. 2018 Jun 7;23 (6) .|[3]Pham TH, et al. Fargesin exerts anti-inflammatory effects in THP-1 monocytes by suppressing PKC-dependent AP-1 and NF-ĸB signaling. Phytomedicine. 2017 Jan 15;24:96-103.|[4]Wang X, et al. Fargesin as a potential β₁ adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis. Fitoterapia. 2015 Sep;105:16-25.