NTPO

NTPO (Nitrilotris methylenephosphonic acid) is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO are abrogated by base excision repair (BER) but not nucleotide excision repair (NER) [1].

Product Specifications

CAS Number

[6419-19-8]

Product Name Alternative

Nitrilotris (methylenephosphonic acid)

UNSPSC

12352211

Hazard Statement

H290

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ntpo.html

Smiles

OP(CN(CP(O)(O)=O)CP(O)(O)=O)(O)=O

Molecular Formula

C3H12NO9P3

Molecular Weight

299.05

Precautions

H290

References & Citations

[1]Choi JY, et al. Non-thermal plasma-induced apoptosis is modulated by ATR- and PARP1-mediated DNA damage responses and circadian clock. Oncotarget. 2016 May 31;7 (22) :32980-9.