NTPO
NTPO (Nitrilotris methylenephosphonic acid) is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO are abrogated by base excision repair (BER) but not nucleotide excision repair (NER) [1].
Product Specifications
CAS Number
6419-19-8
Product Name Alternative
Nitrilotris (methylenephosphonic acid)
UNSPSC
12352211
Hazard Statement
H290
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ntpo.html
Smiles
OP(CN(CP(O)(O)=O)CP(O)(O)=O)(O)=O
Molecular Formula
C3H12NO9P3
Molecular Weight
299.05
Precautions
H290
References & Citations
[1]Choi JY, et al. Non-thermal plasma-induced apoptosis is modulated by ATR- and PARP1-mediated DNA damage responses and circadian clock. Oncotarget. 2016 May 31;7 (22) :32980-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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