Human IL-17 RA/IL-17 RC (Luc) HEK293 Reporter Cell
Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.
Product Specifications
Background
Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.
Host
HEK293
Origin Species
Human
Target
IL-17 RA & IL-17 RC
Tag
Luc
Applications
• Screen for neutralizing antibodies blocking the stimulation of human IL-17A or human IL-17F protein.
Format
Liquid
Shipping Conditions
Dry ice
Storage Conditions
Frozen in liquid nitrogen
Package Size
1Vial*2
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/CHEK-ATF133.pdf
Species
Human
Curated Selection
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