8 (S) -HEPE
8 (S) -HEPE is a monohydroxy fatty acid produced by lipoxygenase oxidation of EPA. It acts to promote hatching of barnacle eggs at 10 nM, although it is not clearly identified as the natural egg hatching factor[1][2].
Product Specifications
CAS Number
118492-81-2
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Lipoxygenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/8-s-hepe.html
Concentration
314.02 μM * 250 μL in Ethanol
Purity
98.0
Smiles
CC/C=C\C/C=C\C/C=C\C=C\[C@@H](O)C/C=C\CCCC(O)=O
Molecular Formula
C20H30O3
Molecular Weight
318.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Hill, et al. Identification and hatching factor activity of monohydroxyeicosapentaenoic acid in homogenates of the barnacle Elminius modestus. Proc. R. Soc. Lond. B Biol. Sci. 234, 455-461 (1988) .|[2]Yamada H, et al. 8 (R) -Hydroxyeicosapentaenoic acid (8R-HEPE) induces transcription of cholesterol efflux receptors via activation of liver X receptor in macrophages. Biosci Biotechnol Biochem. 2023 May 19;87 (6) :584-591.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, protect from light, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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