8 (S) -HEPE

8 (S) -HEPE is a monohydroxy fatty acid produced by lipoxygenase oxidation of EPA. It acts to promote hatching of barnacle eggs at 10 nM, although it is not clearly identified as the natural egg hatching factor[1][2].

Product Specifications

CAS Number

[118492-81-2]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Lipoxygenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/8-s-hepe.html

Concentration

314.02 μM * 250 μL in Ethanol

Purity

98.0

Smiles

CC/C=C\C/C=C\C/C=C\C=C\[C@@H](O)C/C=C\CCCC(O)=O

Molecular Formula

C20H30O3

Molecular Weight

318.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Hill, et al. Identification and hatching factor activity of monohydroxyeicosapentaenoic acid in homogenates of the barnacle Elminius modestus. Proc. R. Soc. Lond. B Biol. Sci. 234, 455-461 (1988) .|[2]Yamada H, et al. 8 (R) -Hydroxyeicosapentaenoic acid (8R-HEPE) induces transcription of cholesterol efflux receptors via activation of liver X receptor in macrophages. Biosci Biotechnol Biochem. 2023 May 19;87 (6) :584-591.