(Rac) -Acolbifene

(Rac) -Acolbifene (EM-343; (Rac) -EM-652) is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities. (Rac) -Acolbifene (EM-343; (Rac) -EM-652) contains a piperidine ring, shows good pharmacological profile, relative binding affinity (RBA) =380[1].

Product Specifications

CAS Number

[151533-34-5]

Product Name Alternative

EM-343; (Rac) -EM-652

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rac-acolbifene.html

Concentration

10mM

Purity

98.18

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C2C(C)=C(C3=CC=C(O)C=C3)C(C4=CC=C(OCCN5CCCCC5)C=C4)OC2=C1

Molecular Formula

C29H31NO4

Molecular Weight

457.56

References & Citations

[1]Gauthier S1, et al.Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution.J Enzyme Inhib Med Chem. 2005 Apr;20 (2) :165-77.