Aminocandin

Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp.[1].

Product Specifications

CAS Number

[227472-48-2]

Product Name Alternative

HMR 3270; IP960; NXL201

UNSPSC

12352209

Target

Fungal

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/aminocandin.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](NC([C@](NC([C@@](C[C@H]1O)([H])N(C1)C2=O)=O)([H])[C@H](O)CC(C=C3)=CC=C3O)=O)CO)N(C[C@@H]4C)[C@@](C(NCC(C[C@@H](C(N[C@@]2([H])[C@H](O)C)=O)NC(C5=CC=C(C(C=C6)=CC=C6OCCCCCCCC)C=C5)=O)NCCN)=O)([H])[C@H]4O

Molecular Formula

C56H79N9O14

Molecular Weight

1102.28

References & Citations

[1]Warn PA, et al. Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus. Int J Antimicrob Agents. 2010 Feb;35 (2) :146-51.|[2]Ghannoum MA, et al. Efficacy of aminocandin in the treatment of immunocompetent mice with haematogenously disseminated fluconazole-resistant candidiasis. J Antimicrob Chemother. 2007 Mar;59 (3) :556-9.