Depulfavirine

RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor (NNRTI) . RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50[1].

Product Specifications

CAS Number

[867365-76-2]

Product Name Alternative

Ro-0335

UNSPSC

12352005

Target

Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ro-0335.html

Purity

99.48

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

ClC1=CC(OC2=C(F)C(CC(NC3=CC=C(S(=O)(N)=O)C=C3Cl)=O)=CC=C2Br)=CC(C#N)=C1

Molecular Formula

C21H13BrCl2FN3O4S

Molecular Weight

573.22

References & Citations

[1]Javanbakht H, et al. In vitro resistance development for RO-0335, a novel diphenylether nonnucleoside reverse transcriptase inhibitor. Antiviral Res. 2010;86 (2) :212-219.