Depulfavirine
RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor (NNRTI) . RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50[1].
Product Specifications
CAS Number
[867365-76-2]
Product Name Alternative
Ro-0335
UNSPSC
12352005
Target
Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ro-0335.html
Purity
99.48
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
ClC1=CC(OC2=C(F)C(CC(NC3=CC=C(S(=O)(N)=O)C=C3Cl)=O)=CC=C2Br)=CC(C#N)=C1
Molecular Formula
C21H13BrCl2FN3O4S
Molecular Weight
573.22
References & Citations
[1]Javanbakht H, et al. In vitro resistance development for RO-0335, a novel diphenylether nonnucleoside reverse transcriptase inhibitor. Antiviral Res. 2010;86 (2) :212-219.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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