Deoxysappanone B

Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan) . Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK) -NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage[1].

Product Specifications

CAS Number

[113122-54-6]

Product Name Alternative

3-Deoxysappanone B

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

P38 MAPK

Type

Natural Products

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/deoxysappanone-b.html

Solubility

10 mM in DMSO

Smiles

O=C1[C@H](CC2=CC=C(O)C(O)=C2)COC3=CC(O)=CC=C13

Molecular Formula

C16H14O5

Molecular Weight

286.28

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Ke-Wu Zeng, et al. Deoxysappanone B, a homoisoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IκB kinase (IKK) -NF-κB and p38/ERK MAPK pathways. Eur J Pharmacol. 2015 Feb 5;748:18-29.