3- (4-Pyridyl) indole
3- (4-Pyridyl) indole (Rockout) is a Rho-kinase (ROCK) inhibitor, with an IC50 of 25 μM. 3- (4-Pyridyl) indole can inhibit blebbing and cause dissolution of actin stress fibers in a wound healing assay[1].
Product Specifications
CAS Number
7272-84-6
Product Name Alternative
Rockout; 3- (4-Pyridinyl) -1H-indole; Rho Kinase Inhibitor III, Rockout
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/3-4-pyridyl-indole.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C1(C2=CC=NC=C2)=CNC3=C1C=CC=C3
Molecular Formula
C13H10N2
Molecular Weight
194.23
Precautions
H302+H312+H332
References & Citations
[1]Yarrow JC, et, al. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem Biol. 2005 Mar;12 (3) :385-95.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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