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3- (4-Pyridyl) indole

3- (4-Pyridyl) indole (Rockout) is a Rho-kinase (ROCK) inhibitor, with an IC50 of 25 μM. 3- (4-Pyridyl) indole can inhibit blebbing and cause dissolution of actin stress fibers in a wound healing assay[1].

Product Specifications

CAS Number

7272-84-6

Product Name Alternative

Rockout; 3- (4-Pyridinyl) -1H-indole; Rho Kinase Inhibitor III, Rockout

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/3-4-pyridyl-indole.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1(C2=CC=NC=C2)=CNC3=C1C=CC=C3

Molecular Formula

C13H10N2

Molecular Weight

194.23

Precautions

H302+H312+H332

References & Citations

[1]Yarrow JC, et, al. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem Biol. 2005 Mar;12 (3) :385-95.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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