Endoxifen (Z-isomer)
Product Specifications
UNSPSC Description
Endoxifen Z-isomer is the most important Tamoxifen metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen Z-isomer inhibits hERG. This effect is concentration-dependent, with an IC50 value of 1.6 μM.
Target Antigen
Estrogen Receptor/ERR; Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Endoxifen-Z-isomer.html
Purity
99.20
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)\CC)C=C1
Molecular Weight
373.49
References & Citations
[1]Chae YJ, et al. Endoxifen, the active metabolite of tamoxifen, inhibits cloned hERG potassium channels. Eur J Pharmacol. 2015 Apr 5;752:1-7.|[2]Wu X, et al. Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 2011 Mar 10;13(2):R27.North Dakota State University of Agriculture and Applied Science. 2018 Feb.|J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Mar 26:1237:124100.|Sci Rep. 2022 Jan 31;12(1):1643.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18719/Endoxifen-Z-isomer-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18719/Endoxifen-Z-isomer-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
112093-28-4
Available Sizes
Curated Selection
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