Merbarone
Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent[1][2][4].
Product Specifications
CAS Number
97534-21-9
Product Name Alternative
NSC 336628
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/merbarone.html
Concentration
10mM
Purity
99.49
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(C(C(N1)=O)C(NC1=S)=O)NC2=CC=CC=C2
Molecular Formula
C11H9N3O3S
Molecular Weight
263.27
References & Citations
[1]Fortune JM, et, al. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. J Biol Chem. 1998 Jul 10;273 (28) :17643-50.|[2]Brewer AD, et, al. 5- (N-phenylcarboxamido) -2-thiobarbituric acid (NSC 336628), a novel potential antitumor agent. Biochem Pharmacol. 1985 Jun 1;34 (11) :2047-50.|[3]Cooney DA, et, al. Initial mechanistic studies with merbarone (NSC 336628) . Biochem Pharmacol. 1985 Sep 15;34 (18) :3395-8.|[4]Chen M, et, al. Differences in inhibition of chromosome separation and G2 arrest by DNA topoisomerase II inhibitors merbarone and VM-26. Cancer Res. 1995 Apr 1;55 (7) :1509-16.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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