Merbarone

Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent[1][2][4].

Product Specifications

CAS Number

[97534-21-9]

Product Name Alternative

NSC 336628

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/merbarone.html

Concentration

10mM

Purity

99.49

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C(C(C(N1)=O)C(NC1=S)=O)NC2=CC=CC=C2

Molecular Formula

C11H9N3O3S

Molecular Weight

263.27

References & Citations

[1]Fortune JM, et, al. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. J Biol Chem. 1998 Jul 10;273 (28) :17643-50.|[2]Brewer AD, et, al. 5- (N-phenylcarboxamido) -2-thiobarbituric acid (NSC 336628), a novel potential antitumor agent. Biochem Pharmacol. 1985 Jun 1;34 (11) :2047-50.|[3]Cooney DA, et, al. Initial mechanistic studies with merbarone (NSC 336628) . Biochem Pharmacol. 1985 Sep 15;34 (18) :3395-8.|[4]Chen M, et, al. Differences in inhibition of chromosome separation and G2 arrest by DNA topoisomerase II inhibitors merbarone and VM-26. Cancer Res. 1995 Apr 1;55 (7) :1509-16.