CMC2.24
CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC50s ranging from 2.0-69 μM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis[1][2][3].
Product Specifications
CAS Number
[1255639-43-0]
Product Name Alternative
TRB-N0224
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; MMP; Ras
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cmc2-24.html
Purity
97.48
Solubility
DMSO : < 1 mg/mL
Smiles
O=C(NC1=CC=CC=C1)C(C(/C=C/C2=CC=C(O)C=C2)=O)C(/C=C/C3=CC=C(O)C=C3)=O
Molecular Formula
C26H21NO5
Molecular Weight
427.45
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120793/CMC2-24-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120793/CMC2-24-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-1; MMP-12; MMP-13; MMP-14; MMP-2; MMP-3; MMP-7; MMP-8; MMP-9
Available Sizes
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