(±) 12-HEPE

(±) 12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12 (S) -HEPE and 12 (R) -HEPE. The biological activity of (±) 12-HEPE is likely mediated by one of the individual isomers, most commonly the 12 (S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 μM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s=8.6-8.8 μM) .

Product Specifications

CAS Number

[81187-21-5]

Product Name Alternative

8-Nitrotryptanthrin

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/racemic-12-hepe.html

Smiles

CC/C=C\C/C=C\CC(O)/C=C/C=C\C/C=C\CCCC(O)=O

Molecular Formula

C20H30O3

Molecular Weight

318.45

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Karanian, et al. Inhibitory effects of n-6 and n-3 hydroxy fatty acids on thromboxane (U46619) -induced smooth muscle contraction. J. Pharmacol. Exp. Ther. 270 (3), 1105-1109 (1994) .