NGP555
NGP555 is a γ-secretase modulator. NGP555 Lowers the Amyloid Biomarker Aβ42[1].
Product Specifications
CAS Number
[1304630-27-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/NGP555.html
Purity
98.77
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=CN(C2=CC=C(C3=CSC(NC4=CC(CC)=C(C)C=C4C)=N3)C=C2F)C=N1
Molecular Formula
C23H23FN4S
Molecular Weight
406.52
Precautions
H302, H315, H319
References & Citations
[1]Kounnas MZ, et al. NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents. Alzheimers Dement (N Y) . 2017 Jan;3 (1) :65-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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