Bropirimine
Bropirimine (U-54461; U-54461S; PNU-54461) is an orally active TLR7 agonist. Bropirimine inhibits RANKL-induced osteoclast differentiation of mouse bone marrow-derived macrophages (BMMs) . Bropirimine exhibits dose-dependent direct inhibitory effects on colony formation of cultured KK-47 and 724 cells. Bropirimine can be used for the study of cancers and bone metabolic disorders such as osteoporosis[1][2][3].
Product Specifications
CAS Number
56741-95-8
Product Name Alternative
U-54461; U-54461S; PNU-54461
UNSPSC
12352005
Hazard Statement
H361
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bropirimine.html
Purity
99.94
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1NC(N)=NC(C2=CC=CC=C2)=C1Br
Molecular Formula
C10H8BrN3O
Molecular Weight
266.10
Precautions
H361
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
TLR7
Available Sizes
Frequently Asked Questions
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