Lactonic sophorolipid

Lactonic sophorolipid is an apoptosis inducer and antimicrobial surfactant with antitumor activity. Lactonic sophorolipid regulates Bax/Bcl-gene expression through caspase-3/9 and induces apoptosis in tumor cells. Lactonic sophorolipid can disrupt cell membrane permeability and exert antibacterial effects (MIC for oral pathogens is 100-400 μg/mL) . Lactonic sophorolipid promotes mitochondrial membrane potential depolarization, activates the intrinsic apoptotic pathway, and can synergize with antibiotics to enhance the antibacterial effect. Lactonic sophorolipid can be used in liver cancer research and the development of oral hygiene antibacterial agents[1][2][3].

Product Specifications

CAS Number

[148409-20-5]

UNSPSC

12352005

Target

Antibiotic; Apoptosis; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/lactonic-sophorolipid.html

Purity

97.31

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@]2([H])[C@@](O[C@H](CCCCCC/C=C\CCCCCCCC(O[C@]3([H])[C@H](O[C@@]([C@@H]([C@H]3O)O)([H])O2)COC(C)=O)=O)C)([H])O[C@@H]([C@H]1O)COC(C)=O

Molecular Formula

C34H56O14

Molecular Weight

688.80

References & Citations

[1]Xiao Wang, et al. Lactonic sophorolipid-induced apoptosis in human HepG2 cells through the Caspase-3 pathway. Appl Microbiol Biotechnol. 2021 Mar;105 (5) :2033-2042.|[2]Callaghan B, et al. Lactonic Sophorolipids Increase Tumor Burden in Apcmin+/-Mice. PLoS One. 2016 Jun 6;11 (6) :e0156845.|[3]M Elshikh, et al. Rhamnolipids and lactonic sophorolipids: natural antimicrobial surfactants for oral hygiene. J Appl Microbiol. 2017 Nov;123 (5) :1111-1123.