Thalidomide-4-O-C6-NH2 (hydrochloride)
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1].
Product Specifications
CAS Number
[2245697-88-3]
UNSPSC
12352005
Hazard Statement
H301, H312, H361
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-4-o-c6-nh2-hydrochloride.html
Purity
98.87
Solubility
DMSO : 83.33 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCCCCCN)=O.[H]Cl
Molecular Formula
C19H24ClN3O5
Molecular Weight
409.86
Precautions
H301, H312, H361
References & Citations
[1]Erb MA, et al. Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 2017 Mar 9;543 (7644) :270-274.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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