MEN 10207

MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

Product Specifications

CAS Number

[126050-12-2]

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/men-10207.html

Purity

99.80

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N=C(N)NCCC[C@@H](C(N)=O)NC([C@@H](CC1=CNC2=CC=CC=C12)NC([C@H](NC([C@H](C(C)C)NC([C@H](NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC3=CC=C(C=C3)O)=O)CC4=CNC5=CC=CC=C45)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O

Molecular Formula

C57H68N14O10

Molecular Weight

1109.24

References & Citations

[1]X J Xu, et al. On the role of NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat. Neuroscience. 1991;44 (2) :483-90.|[2]P Rovero, et al. A highly selective NK-2 tachykinin receptor antagonist containing D-tryptophan. Eur J Pharmacol. 1990 Jan 3;175 (1) :113-5.|[3]A K Henderson, et al. Demonstration of a neurokinin A receptor subtype in transfected fibroblasts. Eur J Pharmacol. 1992 Feb 13;225 (2) :175-8.