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BOP (sodium)

BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with Kd values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins[1][2].

Product Specifications

CAS Number

1947348-42-6

UNSPSC

12352005

Target

Integrin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bop-sodium.html

Purity

99.11

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=C(O[Na])[C@H](CC1=CC=C(OC(N2CCCC2)=O)C=C1)NC([C@H]3N(S(=O)(C4=CC=CC=C4)=O)CCC3)=O

Molecular Formula

C25H28N3NaO7S

Molecular Weight

537.56

References & Citations

[1]R Blake Pepinsky, et al. Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1. Biochemistry. 2002 Jun 4;41 (22) :7125-41.|[2]Benjamin Cao, et al. Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat Commun. 2016 Mar 15;7:11007.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

α4β1; α9β1

Available Sizes

Frequently Asked Questions

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