Terevalefim

Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor[1][2].

Product Specifications

CAS Number

[1070881-42-3]

Product Name Alternative

ANG-3777

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

C-Met/HGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/terevalefim.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1(/C=C/C2=CC=CS2)=NNC=C1

Molecular Formula

C9H8N2S

Molecular Weight

176.24

Precautions

H315, H319, H320

References & Citations

[1]Jonathan S Bromberg, et al. Renal Function Improvement Following ANG-3777 Treatment in Patients at High Risk for Delayed Graft Function After Kidney Transplantation. Transplantation. 2021 Feb 1;105 (2) :443-450.|[2]Latha Paka, et al. The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor, c-MET Signaling. American Transplant Society.