SB 203580 sulfone

SB 203580 sulfone is an analog of p38 MAP kinase inhibitor SB 203580. SB 203580 sulfone inhibits the IL-1 production (IC50 of 0.2 μM in monocytes) and binds competitively with CSAID binding proteins (CSBP), inhibits it mediated stress response signaling with an IC50 of 0.03 μM. SB 203580 sulfone inhibits 5-LO with an IC50 value of 24 µM. SB 203580 sulfone can be used in the research of inflammatory diseases[1][2].

Product Specifications

CAS Number

[152121-46-5]

UNSPSC

12352005

Target

Drug Derivative; Interleukin Related; Lipoxygenase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sb-203580-sulfone.html

Purity

99.25

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 50 mg/mL (ultrasonic; warming)

Smiles

O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)(C)=O

Molecular Formula

C21H16FN3O2S

Molecular Weight

393.43

References & Citations

[1]Gallagher TF, et al., Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase. Bioorg Med Chem. 1997 Jan;5 (1) :49-64.|[2]Timothy F, et al. 2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis. Bioorganic & Medicinal Chemistry Letters, 1995, 1171-1176.