ICOS-IN-1
ICOS-IN-1 (compound 9) is an inhibitor of the interaction between ICOS and ICOS-L (IC50=29.38 μM) and has activity in recognizing immune checkpoints[1].
Product Specifications
CAS Number
[1006002-58-9]
UNSPSC
12352101
Target
CD28
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/icos-in-1.html
Smiles
OC1=C(C2=NNC=C2)C=CC(OCC3=CC=C(Cl)C(Cl)=C3)=C1C
Molecular Formula
C17H14Cl2N2O2
Molecular Weight
349.21
References & Citations
[1]Longfei Zhang, et al. "Discovery of ICOS-targeted small molecules using affinity selection mass spectrometry screening." bioRxiv (2024) : 2024-08.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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