Clociguanil
Clociguanil (BRL 50216), a DHFR inhibitor (IC50: 55.6 nM), is an antimalarial agent. Clociguanil has sympathomimetic and antiarrhythmic action[1][2].
Product Specifications
CAS Number
3378-93-6
Product Name Alternative
BRL 50216
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR) ; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/clociguanil.html
Smiles
NC1=NC(N)=NC(C)(N1OCC2=CC=C(C(Cl)=C2)Cl)C
Molecular Formula
C12H15Cl2N5O
Molecular Weight
316.19
References & Citations
[1]Nettleton MJ, et al. The cardiovascular effects of two new triazine antimalarials, BRL 50216 (Clociguanil) and BRL 6231. Toxicol Appl Pharmacol. 1974 Feb;27 (2) :271-82.|[2]Winstanley PA, et al. In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39 (4) :948-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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