Ceperognastat

Ceperognastat (LY3372689) is an orally active O-GlcNAcase (OGA) enzyme inhibitor. Ceperognastat can be used for tauopathies research, including Alzheimer’s disease[1][2].

Product Specifications

CAS Number

[2241514-56-5]

Product Name Alternative

LY3372689

UNSPSC

12352005

Target

OGA; Tau Protein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly3372689.html

Concentration

10mM

Purity

99.09

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CC(NC1=NC(F)=C(S1)CN2[C@H](C[C@H](CC2)OCC3=NOC(C)=N3)C)=O

Molecular Formula

C16H22FN5O3S

Molecular Weight

383.44

References & Citations

[1]Sergey Shcherbinin, et al. Brain target occupancy of LY3372689, an inhibitor of the O-GlcNAcase (OGA) enzyme: Translation from rat to human. Alzheimer's & Dementia. 07 December 2020 .|[2]Nicolas Jacques Francois Dreyfus, et al. N-[4-fluoro-5-[[ (2s,4s) -2-methyl-4-[ (5-methyl-1,2,4-oxadiazol-3-yl) methoxy]-1-piperidyl]methyl]thiazol-2-yl]acetamide as oga inhibitor. Patent WO2018140299A1.