CTCE-0214

CTCE-0214 is a chemokine CXC receptor 4 (CXCR4) agonist, SDF-1α (stromal cell-derived factor-1α) peptide analog. CTCE-0214 shows anti-inflammatory activity, and can be used in inflammation sepsis and systemic inflammatory syndromes research[1][2][3].

Product Specifications

CAS Number

[577782-52-6]

UNSPSC

12352209

Target

CXCR

Type

Peptides

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ctce-0214.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CNC(CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]1N(CCC1)C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]2N(CCC2)C([C@@H](N)CCCCN)=O)=O)C(C)C)=O)CO)=O)CC(C)C)=O)CO)=O)CC3=CC=C(C=C3)O)=O)CCCNC(N)=N)=O)C)=O)=O)CC4=CC=CC=C4)=O)CCCNC(N)=N)=O)CC5=CC=CC=C5)=O)CC6=CC=CC=C6)=O)=O)=O)=O)=O)CC(C)C)=O)CCCCN7)=O)CC8=CNC9=C8C=CC=C9)=O)[C@H](CC)C)=O)CCC(N)=O)=O)CCC7=O)=O)CC%10=CC=C(C=C%10)O)=O)CC(C)C)=O)CCC(O)=O)=O)CCCCN)=O)C)=O)CC(C)C)=O)C(N)=O)N

Molecular Formula

C170H254N44O40

Molecular Weight

3554.11

References & Citations

[1]Fan H, et al. Beneficial effect of a CXCR4 agonist in murine models of systemic inflammation. Inflammation. 2012 Feb;35 (1) :130-7.|[2]Faber A, et al. The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells. J Biomed Biotechnol. 2007;2007 (3) :26065.|[3]Li K, et al. Small peptide analogue of SDF-1alpha supports survival of cord blood CD34+ cells in synergy with other cytokines and enhances their ex vivo expansion and engraftment into nonobese diabetic/severe combined immunodeficient mice. Stem Cells. 2006 Jan;24 (1) :55-64.