BeKm-1 (TFA)
BeKm-1 TFA is a potent and selective KV11.1 (hERG) channel blocker. BeKm-1 TFA is selective for KV11.1 over a panel of 14 other potassium channels. BeKm-1 TFA dose-dependently prolongs QTc interval in isolated rabbit heart.
Product Specifications
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bekm-1-tfa.html
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)=O.O=C([C@@H](N)CCCNC(N)=N)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]3CCCNC(N)=N)=O)=O)CC(N)=O)=O)[C@@H](C)O)=O)CCCCN)=O)=O)CC4=CC=CC=C4)=O)CCCNC(N)=N)=O)CO)=O)CCCCN)=O)CSSC[C@H](NC5=O)C(N[C@H](C(O)=O)CC6=CC=CC=C6)=O)=O)C(C)C)=O)CCC2)=O)CC7=CC=CC=C7)=O)CSSC[C@H](NC8=O)C(N[C@H]5CC(O)=O)=O)=O)CCC(N)=O)=O)CC9=CC=C(O)C=C9)=O)CO)=O)CCC(O)=O)=O)CO)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H]8CC%10=CC=CC=C%10)=O)=O)CC(N)=O)=O)C(C)C)=O)=O)CCCCN)=O)[C@H](CC)C)=O)CC(O)=O)=O)[C@@H](C)O)=O)CCC1
Molecular Formula
C174H261N51O52S6.xC2HF3O2
Molecular Weight
4091.65 (free acid)
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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