L-Arginine-15N2 (hydrochloride)

L-Arginine-15N2 (hydrochloride) is the 15N-labeled L-Arginine (hydrochloride) . L-Arginine hydrochloride ((S) - (+) -Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

Product Specifications

CAS Number

[204633-92-1]

Product Name Alternative

(S) - (+) -Arginine-15N2 (hydrochloride)

UNSPSC

12352211

Target

Endogenous Metabolite; NO Synthase

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/l-arginine-15n2-hydrochloride.html

Purity

99.97

Solubility

H2O : ≥ 25 mg/mL

Smiles

N[C@H](C(O)=O)CCCNC([15NH2])=[15NH].Cl

Molecular Formula

C6H15ClN2 15N2O2

Molecular Weight

212.65

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002) . Crit Care Med. 2004 Jan;32 (1) :1-12.|[3]Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56 (9) :439-45.|[4]Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20 (4) :709-17.