(R) - (+) -Aminoglutethimide

(R) - (+) -Aminoglutethimide is a potent and orally active aromatase inhibitor. (R) - (+) -Aminoglutethimide has the potential for the research of breast cancer[1].

Product Specifications

CAS Number

[55511-44-9]

Product Name Alternative

D-Aminoglutethimide

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-plus-aminoglutethimide.html

Purity

97.08

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@@](CC)(C1=CC=C(N)C=C1)CC2)NC2=O

Molecular Formula

C13H16N2O2

Molecular Weight

232.28

Precautions

H315, H319, H335

References & Citations

[1]Dai Sig Im, et al. Chemo-enzymatic synthesis of (R) - (+) -aminoglutethimide by kinetic resolution of (±) -4-cyano-4-phenyl-1-hexanol. Journal of Molecular Catalysis B: Enzymatic. 2003, 26:185–191.|[2]Egger H, Bartlett F, Itterly W, Rodebaugh R, Shimanskas C. Metabolism of aminoglutethimide in the rat. Drug Metab Dispos. 1982 Jul-Aug;10 (4) :405-12.