Eragidomide

Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation[1][2].

Product Specifications

CAS Number

[1860875-51-9]

Product Name Alternative

CC-90009

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Ligands for E3 Ligase; Molecular Glues

Type

Reference compound

Related Pathways

Apoptosis; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cereblon-modulator-1.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2)=O)C=C1)C(F)(F)C4=CC=C(Cl)C=C4

Molecular Formula

C22H18ClF2N3O4

Molecular Weight

461.85

Precautions

H302, H315, H319, H335

References & Citations

[1]Christine Surka, et al. CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 2021 Feb 4;137 (5) :661-677.|[2]Joshua D Hansen, et al. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2021 Feb 25;64 (4) :1835-1843.