NSC232003
Product Specifications
UNSPSC Description
NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level.
Target Antigen
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NSC232003.html
Purity
99.67
Solubility
DMSO : < 1 mg/mL|H2O : 2 mg/mL (ultrasonic)
Smiles
O=C1NC(/C(C=N1)=C(NO)/C)=O
Molecular Weight
169.14
References & Citations
[1]Myrianthopoulos V, et al. Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation. Eur J Med Chem. 2016 May 23;114:390-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103236/NSC232003-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103236/NSC232003-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1905453-18-0
Available Sizes
Curated Selection
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