Phospho-PI3K p85 (Y467) + PI3K p55 (Y199) Recombinant Rabbit Monoclonal Antibody [PSH01-39]
Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene. Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
Product Specifications
Product Name Alternative
Abbreviation
PIK3R1, GRB1
Swiss Prot
P27986 Human, P26450 Mouse
Cellular Locus
Cell-cell junction, cis-Golgi network, cytoplasm, cytosol, membrane, nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide within human PIK3R1 aa 451-500 / 724.
Isotype
IgG
Clone
PSH01-39
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell
Positive Control
NIH/3T3 treated with 1mM sodium orthovanadate for 30 minutes whole cell lysate.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 84 kDa/55 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
CAS Number
9000-83-3
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