ZK824190 (hydrochloride)
ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively[1].
Product Specifications
CAS Number
2629177-12-2
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
PAI-1; Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/zk824190-hydrochloride.html
Purity
99.24
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC[C@@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC=C2)=C(F)C=C1F)C(O)=O.[H]Cl
Molecular Formula
C22H21ClF2N2O4
Molecular Weight
450.86
Precautions
H302, H312, H332
References & Citations
[1]Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28 (20) :3372-3375.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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