Triciferol
Product Specifications
UNSPSC Description
Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities[1].
Target Antigen
HDAC; VD/VDR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/triciferol.html
Purity
98.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H]([C@H]1CC[C@@]2([H])/C(CCC[C@]12C)=C/C=C3C[C@@H](O)C[C@H](O)C/3)/C=C(C)/C=C/C(NO)=O
Molecular Weight
429.59
References & Citations
[1]Tavera-Mendoza LE, et al. Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. Proc Natl Acad Sci U S A. 2008;105(24):8250-8255.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131961/Triciferol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131961/Triciferol-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
957214-00-5
Available Sizes
Curated Selection
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