Triciferol

Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities[1].

Product Specifications

CAS Number

[957214-00-5]

UNSPSC

12352211

Target

HDAC; VD/VDR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/triciferol.html

Purity

98.61

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H]([C@H]1CC[C@@]2([H])/C(CCC[C@]12C)=C/C=C3C[C@@H](O)C[C@H](O)C/3)/C=C(C)/C=C/C(NO)=O

Molecular Formula

C26H39NO4

Molecular Weight

429.59

References & Citations

[1]Tavera-Mendoza LE, et al. Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. Proc Natl Acad Sci U S A. 2008;105 (24) :8250-8255.